What is the most common site of lipid accumulation in the human body?
Fat accumulation in the liver cells is the earliest and most common response to alcohol metabolism in the liver.
What is lipid accumulation?
Lipid accumulation product (LAP) is an index, which combines waist circumference (WC) and triglyceride (TG) reflecting lipid accumulation .
Why is leakage of lysosomal enzymes during chemical injury?
What is a consequence of leakage of lysosomal enzymes during chemical injury ? Enzymatic digestion of the nucleus and nucleolus occurs, halting DNA synthesis. During cell injury caused by hypoxia, an increase in the osmotic pressure occurs within the cell because: Sodium chloride enters the cell.
Why does sodium accumulate in a hypoxic cell?
a. The cell membrane permeability increases for sodium during periods of hypoxia . In metabolic failure caused by hypoxia , reduced ATP and ATPase levels permit sodium to accumulate in the cell , whereas potassium diffuses outward. The other options do not accurately describe the cause of the swelling caused by hypoxia .
What is the most common site of lipid accumulation quizlet?
Although lipids sometimes accumulate in heart and kidney cells, the most common site of intracellular lipid accumulation , or fatty change, is liver cells. Subcutaneous tissue is not a common site of lipid accumulation .
How is lipid stored in the body?
Lipids are stored in the body in different forms such as, triglycerides, fat cells, cell membranes and lipoproteins. Any excess energy consumed is converted to triglycerides which together with globules make up 90% of the fat cells. These fat cells contain enough energy storage to keep the body functioning for 30 days.
What happens when you have too many lipids?
When you have too many lipids in your blood, doctors call this hyperlipidemia. It means you have high cholesterol or high triglycerides. Over time, this can cause atherosclerosis, or hardening of the arteries. Cholesterol is a waxy fat-like substance that your body needs to make hormones and vitamin D.
Where are lipid stored?
Lipids or fats are stored in cells throughout the body principle in special kinds of connective tissue called adipose tissue or depot fat.
What cell organelle uses lipids?
The endoplasmic reticulum is an organelle that is responsible for the synthesis of lipids and the modification of proteins.
What are examples of adaptive cellular responses?
Atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia. Adaptive cellular responses also include intracellular accumulations and storage of products in abnormal amounts. The decrease in cell size.
What is the consequence of plasma membrane damage to the mitochondria?
The most serious consequence of plasma membrane damage is, as in hypoxic injury, to the mitochondria . An influx of calcium ions from the extracellular compartment activates multiple enzyme systems, resulting in cytoskeleton disruption, membrane damage , activation of inflammation, and eventually DNA degradation.
Why is potassium able to diffuse easily in and out of cells?
Therefore, potassium can diffuse through the membrane but sodium cannot. Because the membrane is permeable to potassium ions, they will flow down their concentration gradient; i.e. towards the outside of the cell .
What happens when cells become hypoxic?
Hypoxic injury results in an inadequate flow of nutrients and oxygen to the cell. If tissue perfusion continues to be insufficient, hypoxia occurs and the cell resorts to anaerobic metabolic pathways for energy production.
How does hypoxia cause pain?
When the tissue is unable to extract adequate oxygen, the partial pressure of oxygen within the tissue falls ( hypoxia ) leading to a reduction in mitochondrial respiration and oxidative metabolism. If the hypoxic state is prolonged, cellular death may occur. Ischemia can also lead to ischemic pain .
Why does a cell swell in hypoxic injury?
Irrespective of the nature of the initial injury , hypoxia is often the ultimate cause of acute cell swelling because it results in adenosine triphosphate depletion. The hypoxic cell then swells because of loss of volume control when membrane adenosine triphosphatase ionic pumps fail.